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. 1978 Oct;75(10):5001-5.
doi: 10.1073/pnas.75.10.5001.

Induction of ornithine decarboxylase activity in a temperature-sensitive cell cycle mutant of Chinese hamster cells

F Landy-Otsuka, I E Scheffler

Induction of ornithine decarboxylase activity in a temperature-sensitive cell cycle mutant of Chinese hamster cells

F Landy-Otsuka et al. Proc Natl Acad Sci U S A. 1978 Oct.

Abstract

We have investigated the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in a temperature-sensitive cell cycle mutant of Chinese hamster fibroblasts. This activity is not induced at the nonpermissive temperature, although the synthesis of the majority of proteins is normal. From a combination of studies with inhibitors of mRNA synthesis and maturation (alpha-amanitin, and cordycepin) and of proteins synthesis (cycloheximide, diphtheria toxin, and emetine), we conclude that the temperature-sensitive block is at the level of translation of one or more specific mRNAs.

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