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. 2018 Mar-Apr;84(2):206-211.
doi: 10.1016/j.bjorl.2017.02.001. Epub 2017 Feb 27.

Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Mitat Arıcıgil  1 , Mehmet Akif Dündar  2 , Abitter Yücel  3 , Hamdi Arbağ  2 , Abdullah Arslan  4 , Meryem Aktan  5 , Sıdıka Fındık  6 , İbrahim Kılınç  7
Affiliations

Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Mitat Arıcıgil et al. Braz J Otorhinolaryngol. 2018 Mar-Apr.

Abstract
in English, Portuguese

Introduction: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications.

Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day.

Methods: Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day.

Results: Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-α, interleukin-1β, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interleukin-10 was higher in the radiotherapy plus hyperbaric oxygen group.

Conclusion: When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury.

Introdução: O manejo das complicações da irradiação do tecido da cabeça e pescoço é uma questão desafiadora para o otorrinolaringologista. O tratamento definitivo dessas complicações ainda é controverso. Recentemente, a oxigenoterapia hiperbárica tem sido uma opção promissora para estas complicações.

Objetivo: Nesse estudo foram utilizados métodos bioquímicos e histopatológicos para investigar a eficácia do oxigênio hiperbárico contra os efeitos inflamatórios da radioterapia no sangue e nos tecidos laríngeos, quando a radioterapia e oxigênio hiperbárico são administrados no mesmo dia.

Métodos: Trinta e dois ratos Wistar albinos foram divididos em quatro grupos. O grupo controle não recebeu tratamento, o grupo de oxigênio hiperbárico recebeu apenas oxigenoterapia hiperbárica, o grupo de radioterapia recebeu apenas radioterapia e o grupo de radioterapia com oxigênio hiperbárico recebeu ambos os tratamentos no mesmo dia.

Resultados: Foram realizadas avaliações histopatológicas e bioquímicas dos espécimes. Os níveis séricos de fator de necrose tumoral-α, interleucina-1β e inflamação tecidual foram significativamente maiores no grupo de radioterapia do que no grupo de radioterapia mais oxigênio hiperbárico, enquanto que a interleucina-10 foi maior no grupo de radioterapia mais oxigênio hiperbárico.

Conclusão: Quando a radioterapia e o oxigênio hiperbárico são administrados no mesmo dia, as citocinas inflamatórias e a inflamação tecidual podem ser reduzidas no período inicial da radiação.

Keywords: Hyperbaric oxygen; Inflamação; Inflammation; Neck radiotherapy; Oxigênio hiperbárico; Radioterapia de pescoço.

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Figures

Figure 1
Figure 1
Representative photomicrographs of cartilage histology in the control, HBO2, RT and RT + HBO2 groups. Control group: (A) general appearance of H&E (×20); (B) Immunohistochemical LCA (×20). RT group: (C) H&E (×100) black arrow squamous metaplasia – blue arrow columnar epithelium. (D) Immunohistochemical LCA (×40) yellow arrow LCA positive lymphocytes. HBO2 group: (E) H&E (×20) general appearance; (F) Immunohistochemical LCA (×20). RT + HBO2 group: (G) H&E (×100) black arrows quamous metaplasia – blue arrow columnar epithelium; (H) Immunohistochemical LCA (×100) yellow arrow LCA positive lymphocytes.
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References

    1. Gilyoma J.M., Rambau P.F., Masalu N., Kayange N.M., Chalya P.L. Head and neck cancers: a clinico-pathological profile and management challenges in a resource-limited setting. BMC Res Notes. 2015;12:772. - PMC - PubMed
    1. Bekiroglu F., Wright S., Grew N. Chondroradionecrosis of larynx following radiotherapy for metastatic neck disease originating from oral carcinoma. Int J Oral Maxillofac Surg. 2007;36:459–461. - PubMed
    1. Vudiniabola S., Pirone C., Williamson J., Goss A.N. Hyperbaric oxygen in the therapeutic management of osteoradionecrosis of the facial bones. Int J Oral Maxillofac Surg. 2000;29:435–438. - PubMed
    1. Lopez-Jornet P., Gómez-García F., García Carrillo N., Valle-Rodríguez E., Xerafin A., Vicente-Ortega V. Radioprotective effects of lycopene and curcumin during local irradiation of parotid glands in Sprague Dawley rats. Br J Oral Maxillofac Surg. 2016;54:275–279. - PubMed
    1. Shinomiya N. New concepts in radiation-induced apoptosis: ‘premitotic apoptosis’ and ‘postmitotic apoptosis’. J Cell Mol Med. 2001;5:240–253. - PMC - PubMed

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