Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan;79(1):511-514.
doi: 10.1002/mrm.26672. Epub 2017 Mar 25.

Investigating the physiological effects of 10.5 Tesla static field exposure on anesthetized swine

Yigitcan Eryaman  1 , Patrick Zhang  1 , Lynn Utecht  1 , Kivanc Kose  2 , Russell L Lagore  1 , Lance DelaBarre  1 , Jeramy Kulesa  1 , Lynn E Eberly  3 , Gregor Adriany  1 , Tinen L Iles  4 , Paul A Iaizzo  4 , J Thomas Vaughan  1 , Kamil Ugurbil  1
Affiliations

Investigating the physiological effects of 10.5 Tesla static field exposure on anesthetized swine

Yigitcan Eryaman et al. Magn Reson Med. 2018 Jan.

Abstract

Purpose: In this work, we investigated the relative effects of static magnetic field exposure (10.5 Tesla [T]) on two physiological parameters; blood pressure (BP) and heart rate (HR).

Methods: In vivo, we recorded both BP and HR in 4 swine (3 female, 1 male) while they were positioned within a 10.5T magnet. All measurements were performed invasively within these anesthetized animals by the placement of pressure catheters into their carotid arteries.

Results: We measured average increases of 2.0 mm Hg (standard deviation [SD], 6.9) in systolic BP and an increase of 4.5 mm Hg (SD, 13.7) in the diastolic BPs: We also noted an average increase of 1.2 beats per minute (SD, 2.5) in the HRs during such.

Conclusion: Data regarding changes in BP and HR in anesthetized swine attributed to whole-body 10.5T exposure are reported. Magn Reson Med 79:511-514, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Keywords: 10.5T; blood pressure; heart rate; physiological effects; static field exposure.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The waveform as obtained by the data acquisition system is shown. Analysis was made after the experiment to calculate the systolic /diastolic pressures and the heart rate.
Figure 2
Figure 2
Mean and standard deviation value of blood pressure and heart rate obtained from 4 swine are shown for 3 different measurement sets. Error bars denote the within-condition within-swine standard deviation.
Figure 3
Figure 3
Width of the confidence intervals (for changes in the mean systolic BP, ΔSBP) based on the standard deviation is shown. The variation of the confidence interval was useful to determine the minimal number of animals required for this work. Figure also shows the comparison of our confidence interval to the report by Nakao et. al. (11) who monitored left ventricular systolic blood pressure (LVSP) changes in swine caused by moving the animals to various anatomical positions (rolling from supine to left lateral and supine to right lateral).
Figure 4
Figure 4
The mean value of the blood pressure due to different land-marking conditions are shown. Error bars denote the within condition within-swine standard deviation.
See this image and copyright information in PMC

References

    1. Hartmann J. Theory of the laminar flow of an electrically conductive liquid in a homogeneous magnetic field. K Dan Vidensk Selsk Mat Fys Medd. 1937;15(6):1–28.
    1. Hartmann J, Lazarus F. Experimental investigations on the flow of mercury in a homogeneous magnetic field. K Dan Vidensk Selsk Mat Fys Medd. 1937;15(7):1–45.
    1. HIRSCH FG, et al. “THE ELECTRICAL CONDUCTIVITY OF BLOOD” I RELATIONSHIP TO ERYTHROCYTE CONCENTRATION. 1950;5(11):1017–1035. - PubMed
    1. Gaffey CT, et al. A Study of the Influence of Stationary Magnetic-Fields on the Electrocardiographic Indexes and Blood-Pressure of Monkeys. Biophysical Journal. 1982;37(2):A344–A344.
    1. Keltner, et al. Magnetohydrodynamics of Blood Flow. Magn Reson Med. 1990;16:139–149. - PubMed