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. 1978 Oct;75(10):5214-6.
doi: 10.1073/pnas.75.10.5214.

Changes in transmitter release induced by ion-containing liposomes

R Rahamimoff, H Meiri, S D Erulkar, Y Barenholz

Changes in transmitter release induced by ion-containing liposomes

R Rahamimoff et al. Proc Natl Acad Sci U S A. 1978 Oct.

Abstract

The changes in quantal transmitter release induced by egg phosphatidylcholine liposomes with different internal ionic composition were examined at the frog neuromuscular junction by using conventional electrophysiological techniques. It was found that liposomes containing calcium or sodium ions increase both evoked and spontaneous transmitter release, while liposomes containing potassium do not. The results suggest that phosphatidylcholine liposomes are able to transfer their aqueous medium into the presynaptic nerve terminal.

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