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Editorial
. 2017 Jul:109:145-146.
doi: 10.1016/j.lungcan.2017.03.005. Epub 2017 Mar 18.

Targeting BAP1: a new paradigm for mesothelioma

L M Schunselaar  1 , W Zwart  2 , P Baas  3
Affiliations
Editorial

Targeting BAP1: a new paradigm for mesothelioma

L M Schunselaar et al. Lung Cancer. 2017 Jul.

Abstract

New treatment strategies for malignant pleural mesothelioma (MPM) are important. BAP1 mutations are present in 47-67% of the MPM tumors, making this a good target for treatment. Multiple functions of BAP1 are investigated in the preclinical situation. Due to many functions of BAP1, the phenotypic effect of BAP1 is diverse. Preclinical data on inhibitors reversing these phenotypic effects are promising. However, the mechanism of BAP1 is not fully elucidated yet and further research about the mechanism and possible inhibitors is necessary.

Keywords: BAP1; Inhibitor; Loss; Malignant mesothelioma; Mutation; Targeting.

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