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Case Reports
. 2017 Jun:59:25-28.
doi: 10.1016/j.ijid.2017.03.013. Epub 2017 Mar 22.

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses

Jenneke Leentjens  1 , Mark S Gresnigt  2 , Frank L van de Veerdonk  2 , Matthijs Kox  3 , Bart Jan Kullberg  2 , Peter Pickkers  3 , Annemarie E Brouwer  4 , Mihai G Netea  5
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Free article
Case Reports

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses

Jenneke Leentjens et al. Int J Infect Dis. 2017 Jun.
Free article

Abstract

Despite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery.

Keywords: Cerebral abscess; IFN-gamma; Immunotherapy; Nocardia; Nocardiosis.

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