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Case Reports
. 1988 Mar;41(3):280-3.
doi: 10.1136/jcp.41.3.280.

Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA

A P Zarod  1 , J D Rutherford, G Corbitt
Affiliations
Case Reports

Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA

A P Zarod et al. J Clin Pathol. 1988 Mar.

Abstract

A case of laryngeal squamous papilloma in the early stages of development showed histological features suggestive of virus infection. Five years later positive evidence of HPV-6 infection was obtained at a time when the lesion had developed into a squamous cell carcinoma. It is concluded that this case represents a complete example of the virus to papilloma to carcinoma sequence, and as far as is known, is the first reported case of its kind in the larynx.

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