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. 1988 Mar;41(3):320-3.
doi: 10.1136/jcp.41.3.320.

Distribution of vitamin B12 R-binder in carcinomas of the digestive tract

H Kudo  1 , G Ohshio, K Ogawa, Y C Kim, Y Wakatsuki, Y Nakashima, H Yamabe, M Inada
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Distribution of vitamin B12 R-binder in carcinomas of the digestive tract

H Kudo et al. J Clin Pathol. 1988 Mar.

Abstract

To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.

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