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Review
. 2015 Dec 28;6(1):3.
doi: 10.3390/nano6010003.

Receptor-Mediated Drug Delivery Systems Targeting to Glioma

Shanshan Wang  1 , Ying Meng  2 , Chengyi Li  3 , Min Qian  4 , Rongqin Huang  5
Affiliations
Review

Receptor-Mediated Drug Delivery Systems Targeting to Glioma

Shanshan Wang et al. Nanomaterials (Basel). .

Abstract

Glioma has been considered to be the most frequent primary tumor within the central nervous system (CNS). The complexity of glioma, especially the existence of the blood-brain barrier (BBB), makes the survival and prognosis of glioma remain poor even after a standard treatment based on surgery, radiotherapy, and chemotherapy. This provides a rationale for the development of some novel therapeutic strategies. Among them, receptor-mediated drug delivery is a specific pattern taking advantage of differential expression of receptors between tumors and normal tissues. The strategy can actively transport drugs, such as small molecular drugs, gene medicines, and therapeutic proteins to glioma while minimizing adverse reactions. This review will summarize recent progress on receptor-mediated drug delivery systems targeting to glioma, and conclude the challenges and prospects of receptor-mediated glioma-targeted therapy for future applications.

Keywords: blood-brain barrier (BBB); dual ligand-modified targeting systems; glioma; receptor-mediated; single ligand-modified targeting systems.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of single ligand-modified targeting systems.
Figure 2
Figure 2
Design of the DOX-loaded GSPI-based system as a multifunctional drug delivery system for combined chemo-photothermal targeted glioma therapy.
See this image and copyright information in PMC

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