Interventions for preventing silent cerebral infarcts in people with sickle cell disease
- PMID: 28344510
- PMCID: PMC5360228
- DOI: 10.1002/14651858.CD012389
Interventions for preventing silent cerebral infarcts in people with sickle cell disease
Update in
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Interventions for preventing silent cerebral infarcts in people with sickle cell disease.Cochrane Database Syst Rev. 2017 May 13;5(5):CD012389. doi: 10.1002/14651858.CD012389.pub2. Cochrane Database Syst Rev. 2017. Update in: Cochrane Database Syst Rev. 2020 Apr 6;4:CD012389. doi: 10.1002/14651858.CD012389.pub3. PMID: 28500860 Free PMC article. Updated.
Abstract
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effectiveness of red blood transfusions and hydroxyurea alone or in combination and HSCT to reduce or prevent SCI in people with SCD.
Conflict of interest statement
Declarations of Interest Lise Estcourt: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components.Patricia Fortin: funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components.Sally Hopewell: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components.Marialena Trivella: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components.Miguel Abboud: has received research funding from Mast Therapeutics, Eli Lilly, Shire, Dilaforette, he also serves on advisory boards and steering committees for Eli Lilly, Pfizer, Astra Zeneca and Novo. These activities had no relationship to the management of neurologic complications in sickle cell disease.
References
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- Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. New England Journal of Medicine 1998;339(1):5‐11. - PubMed
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- Adekile AD, Yacoub F, Gupta R, Sinan T, Haider MZ, Habeeb Y, et al. Silent brain infarcts are rare in Kuwaiti children with sickle cell disease and high Hb F. Americal Journal of Hematology 2002;70(3):228‐31. - PubMed
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