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. 2016 Oct;2016(10):CD012380.
doi: 10.1002/14651858.CD012380.

Interventions for chronic kidney disease in people with sickle cell disease

Noemi Ba Roy  1 , Patricia M Fortin  2 , Katherine R Bull  3 , Carolyn Doree  2 , Marialena Trivella  4 , Sally Hopewell  5 , Lise J Estcourt  6
Affiliations

Interventions for chronic kidney disease in people with sickle cell disease

Noemi Ba Roy et al. Cochrane Database Syst Rev. 2016 Oct.

Update in

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effectiveness of any intervention in preventing or reducing kidney complications or CKD in people with SCD (including red blood cell transfusions, hydroxyurea and ACEI (either alone or in combination with each other)).

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Conflict of interest statement

Declarations of Interest Noemi Roy: none known. Patricia Fortin: funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components. Katherine Bull: none known. Carolyn Doree: none known. Sally Hopewell: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components. Marialena Trivella: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components. Lise Estcourt: partly funded by the NIHR Cochrane Programme Grant - Safe and Appropriate Use of Blood Components.

Figures

Figure 1
Figure 1
Sickle cell nephropathy pathophysiology in sickle cell disease: Adapted fromOkafor 2013andNath 2015 RBC: red blood cells; FSGS: focal segmental glomerulosclerosis; ESRD: end‐stage renal disease
Figure 2
Figure 2
Structure of the kidney. From: Wikispaces. Human Physiology. 12. Urology.https://humanphysiology2011.wikispaces.com/12.+Urology
See this image and copyright information in PMC

References

    1. Adam S, Jonassaint J, Kruger H, Kail M, Orringer EP, Eckman JR, et al. Surgical and obstetric outcomes in adults with sickle cell disease. American Journal of Medicine 2008;121(10):916‐21. - PMC - PubMed
    1. Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin C T, Sebastiani P, et al. Fetal hemoglobin in sickle cell anemia. Blood 2011;118(1):19‐27. - PMC - PubMed
    1. Alvarez O, Montane B, Lopez G, Wilkinson J, Miller T. Early blood transfusions protect against microalbuminuria in children with sickle cell disease. Pediatric Blood & Cancer 2006;47:71‐6. - PubMed
    1. Alvarez O, Miller ST, Wang WC, Luo Z, McCarville MB, Schwartz GJ, et al. Effect of hydroxyurea treatment on renal function parameters: results from the multi‐center placebo‐controlled BABY HUG clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer 2012;59(4):668‐74. - PMC - PubMed
    1. Arlet JB, Ribeil JA, Chatellier G, Eladari D, Seigneux S, Souberbielle JC, et al. Determination of the best method to estimate glomerular filtration rate from serum creatinine in adult patients with sickle cell disease: a prospective observational cohort study. BMC Nephrology 2012;13:83. - PMC - PubMed