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Review
. 2017 Feb 1;18(2):295-314.
doi: 10.22034/APJCP.2017.18.2.295.

Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences

Mehdi Nematbakhsh  1 , Zahra Pezeshki, Fatemeh Eshraghi Jazi, Bahar Mazaheri, Maryam Moeini, Tahereh Safari, Fariba Azarkish, Fatemeh Moslemi, Maryam Maleki, Alireza Rezaei, Shadan Saberi, Aghdas Dehghani, Maryam Malek, Azam Mansouri, Marzieh Ghasemi, Farzaneh Zeinali, Zohreh Zamani, Mitra Navidi, Sima Jilanchi, Soheyla Shirdavani, Farzaneh Ashrafi
Affiliations
Review

Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences

Mehdi Nematbakhsh et al. Asian Pac J Cancer Prev. .

Abstract

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and discussed with suggestions included for future work.

Keywords: Cisplatin; nephrotoxicity; antioxidant; trace elements; herbal agents; gender.

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