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Review
. 2017 Apr;18(5):421-426.
doi: 10.2217/pgs-2017-0028. Epub 2017 Mar 27.

Institutional profile: University of Florida Health Personalized Medicine Program

Larisa H Cavallari  1   2   3 , Kristin W Weitzel  1   2   3 , Amanda R Elsey  1   3 , Xinyue Liu  4 , Scott A Mosley  1   2 , Donald M Smith  1   2 , Benjamin J Staley  4   5 , Almut G Winterstein  4   6 , Carol A Mathews  7 , Francesco Franchi  8 , Fabiana Rollini  8 , Dominick J Angiolillo  8 , Petr Starostik  9 , Michael J Clare-Salzler  3   9 , David R Nelson  2   10 , Julie A Johnson  1   2   3   10
Affiliations
Review

Institutional profile: University of Florida Health Personalized Medicine Program

Larisa H Cavallari et al. Pharmacogenomics. 2017 Apr.

Abstract

The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and established the infrastructure at UF Health to support clinical implementation for five additional gene-drug pairs: TPMT-thiopurines, IFNL3 (IL28B)-PEG IFN-α-based regimens, CYP2D6-opioids, CYP2D6/CYP2C19-antidepressants and CYP2C19-proton pump inhibitors. We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs for providers, trainees and students that incorporate personal genotype evaluation to enhance participant learning.

Keywords: PEG-interferon; clopidogrel; education; genotype; implementation; opioids; pharmacogenetics; proton pump inhibitors; selective serotonin uptake inhibitors; thiopurines.

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Conflict of interest statement

Financial & competing interests disclosure

This work was supported by the NIH grant U01 HG007269, as part of the NIH IGNITE network. Additional support provided by NIH U01 GM074492 and U01 HL105198 (both part of the NIH Pharmacogenomics Research Network), and by substantial institutional support from the University of Florida and its Clinical Translational Science Institute (UL1 TR000064 and UL1 TR001427). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Timeline of launch of pharmacogenetic implementations at University of Florida Health.
See this image and copyright information in PMC

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