Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 May;85(9):2959-63.
doi: 10.1073/pnas.85.9.2959.

Interaction of origin binding protein with an origin of replication of herpes simplex virus 1

P Elias  1 , I R Lehman
Affiliations

Interaction of origin binding protein with an origin of replication of herpes simplex virus 1

P Elias et al. Proc Natl Acad Sci U S A. 1988 May.

Abstract

Herpes simplex virus 1 encodes a protein that binds specifically to a viral DNA replication origin (oriS). This origin-binding protein has been purified to homogeneity by means of sequence-specific DNA affinity chromatography. The purified origin-binding protein, which has a molecular weight of 83,000, interacts with both parts of the oriS dyad; however, the affinity for the two sites differs by an order of magnitude. The sequence TTCGCA occurs as a nearly perfect direct repeat within the two sites and may constitute the recognition sequence for the origin-binding protein.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9094-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Feb;78(2):742-6 - PubMed
    1. Nucleic Acids Res. 1981 Jul 10;9(13):3047-60 - PubMed
    1. Anal Biochem. 1981 Sep 1;116(1):53-64 - PubMed

Publication types

LinkOut - more resources