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. 2016 Jan:39:e201.
doi: 10.1017/S0140525X15001727.

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Chadi G Abdallah  1 , Lynnette A Averill  1 , John H Krystal  1 , Steven M Southwick  1 , Amy F T Arnsten  1
Affiliations

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Chadi G Abdallah et al. Behav Brain Sci. 2016 Jan.

Abstract

Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.

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