HIV: Persistence through division
- PMID: 28348204
- PMCID: PMC5379988
- DOI: 10.1084/jem.20170463
HIV: Persistence through division
Abstract
A long-lived latent reservoir for HIV-1 persists in CD4+ T cells despite antiretroviral therapy and is the major barrier to cure. In this issue of JEM, Hosmane et al. show that T cell proliferation could explain the long-term persistence of this reservoir.
© 2017 Cohn and Nussenzweig.
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Comment on
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Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics.J Exp Med. 2017 Apr 3;214(4):959-972. doi: 10.1084/jem.20170193. Epub 2017 Mar 24. J Exp Med. 2017. PMID: 28341641 Free PMC article.
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