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Case Reports
. 2017 Feb 28;4(2):e005085.
doi: 10.1099/jmmcr.0.005085. eCollection 2017 Feb.

Successful treatment of Listeria monocytogenes prosthetic valve endocarditis using rifampicin and benzylpenicillin in combination with valve replacement

Tasnim Hasan  1 , William Chik  2 , Sharon Chen  3 , Jen Kok  4
Affiliations
Case Reports

Successful treatment of Listeria monocytogenes prosthetic valve endocarditis using rifampicin and benzylpenicillin in combination with valve replacement

Tasnim Hasan et al. JMM Case Rep. .

Abstract

Introduction.Listeria monocytogenes is an uncommon cause of prosthetic valve endocarditis (PVE). Recommended antimicrobial therapy typically includes intravenous β-lactams with or without synergistic aminoglycosides. In vitro studies have previously identified antagonism when rifampicin has been used in combination with β-lactams. However, in vivo data of rifampicin use are limited despite its enhanced anti-biofilm activity. Case presentation. A 63-year-old male presented with fever and back pain. L. monocytogenes bacteraemia and bioprosthetic aortic valve endocarditis was confirmed, along with spinal discitis and osteomyelitis. He was successfully treated with benzylpenicillin and rifampicin, in conjunction with valve replacement. Conclusion. Rifampicin remains an alternate agent to use, when there are contraindications to traditional aminoglycoside therapy. Further data on rifampicin use in L. monocytogenes PVE are awaited.

Keywords: Listeria; endocarditis; prosthetic valve; rifampicin.

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Figures

Fig. 1.
Fig. 1.
Transoesophageal echocardiograph of the bioprosthetic aortic valve.
See this image and copyright information in PMC

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