Commentary: Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study)
- PMID: 28348975
- PMCID: PMC5346538
- DOI: 10.3389/fonc.2017.00031
Commentary: Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study)
Keywords: EGFR; HER3 inhibitors; Nrg1; cetuximab; squamous cell carcinoma of the head and neck.
Comment on
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Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study).Front Oncol. 2016 Oct 31;6:232. doi: 10.3389/fonc.2016.00232. eCollection 2016. Front Oncol. 2016. PMID: 27843803 Free PMC article.
References
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- Wang D, Qian G, Zhang H, Magliocca KR, Nannapaneni S, Amin ARMR, et al. HER3 targeting sensitizes HNSCC to cetuximab by reducing HER3 activity and HER2/HER3 dimerization – evidence from cell line and patient derived xenograft models. Clin Cancer Res (2016).10.1158/1078-0432.CCR-16-0558 - DOI - PMC - PubMed
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- Machiels JPH, Haddad RI, Fayette J, Licitra LF, Tahara M, Vermorken JB, et al. Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial. Lancet Oncol (2015) 16(5):583–94.10.1016/S1470-2045(15)70124-5 - DOI - PubMed
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