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Review
. 2016 Nov 1;4(1):24-40.
doi: 10.1080/23328940.2016.1254136. eCollection 2017.

Regulation of thermoTRPs by lipids

Sara L Morales-Lázaro  1 , Luis Lemus  1 , Tamara Rosenbaum  1
Affiliations
Review

Regulation of thermoTRPs by lipids

Sara L Morales-Lázaro et al. Temperature (Austin). .

Abstract

The family of Transient Receptor Potential (TRP) ion channels is constituted by 7 subfamilies among which are those that respond to temperature, the thermoTRPs. These channels are versatile molecules of a polymodal nature that have been shown to be modulated in various fashions by molecules of a lipidic nature. Some of these molecules interact directly with the channels on specific regions of their structures and some of these promote changes in membrane fluidity or modify their gating properties in response to their agonists. Here, we have discussed how some of these lipids regulate the activity of thermoTRPs and included some of the available evidence for the molecular mechanisms underlying their effects on these channels.

Keywords: PIP2; TRP channels; cholesterol; lysophosphatidic acid; lysophosphatidylcholine; monounsaturated fatty acids; oleic acid; thermoTRP.

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Figures

Figure 1.
Figure 1.
Chemical structures of lipid molecules that regulate the function of thermoTRPs.
Figure 2.
Figure 2.
Colesterol interacts with a CRAC motif in the TRPV1 channel. Docking simulation of cholesterol's interactions with the CRAC motif in the S5 transmembrane segment of TRPV1. The cryo-EM structure of TRPV1 in the closed state (PDB 3J5P, chain A) was used and constructed using UCSD-Chimera.
See this image and copyright information in PMC

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