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. 1988 Apr 29;152(2):605-11.
doi: 10.1016/s0006-291x(88)80081-0.

Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani

A K Chakraborty  1 , H K Majumder
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Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani

A K Chakraborty et al. Biochem Biophys Res Commun. .

Abstract

Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs.

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