Shaping the gut microbiome from the pancreas

Wei Wong¹

Affiliations

Comment

Wei Wong. Sci Signal. 2017.

. 2017 Mar 28;10(472):eaan3016.

doi: 10.1126/scisignal.aan3016.

Wei Wong¹

Abstract

The intracellular Ca²⁺ channel Orai1 in pancreatic acinar cells helps to suppress inflammation-associated bacterial strains in the gut.

Beyond Digestion: The Pancreas Shapes Intestinal Microbiota and Immunity.
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Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity.
Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S. Ahuja M, et al. Cell Metab. 2017 Mar 7;25(3):635-646. doi: 10.1016/j.cmet.2017.02.007. Cell Metab. 2017. PMID: 28273482 Free PMC article.