Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2017 Mar 15:12:897-905.
doi: 10.2147/COPD.S129974. eCollection 2017.

Clinical application value of impulse oscillometry in geriatric patients with COPD

Zhonghui Liu  1 , Lianjun Lin  1 , Xinmin Liu  1
Affiliations
Comparative Study

Clinical application value of impulse oscillometry in geriatric patients with COPD

Zhonghui Liu et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Background: The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clinical application value of IOS in geriatric patients with COPD remains unclear.

Aim: The aim of this study was to investigate the clinical application value of IOS in geriatric patients with COPD.

Subjects and methods: A total of 234 subjects were retrospectively enrolled in this study, including 133 patients with COPD and 101 healthy volunteers. All the participants underwent IOS and spirometry examination. The data were collected and analyzed in the overall group, the geriatric group (aged ≥65 years), and the advanced elderly group (aged ≥80 years).

Results: 1) In COPD patients, a significant increase in respiratory impedance (Z5), resonant frequency (Fres), and respiratory resistance (R5, R20, R5-R20) and a decrease in respiratory reactance (X5) were observed in the overall group, the geriatric group, and the advanced elderly group compared with the healthy control subjects. 2) The IOS parameters correlated well with spirometry in COPD. In particular, R5-R20 showed the best correlation with forced expiratory volume in 1 second (FEV1) in the different age groups. 3) Fres and R5-R20 had the best diagnostic efficiency for COPD. The area under the curve (AUC) values for Fres, expressed by the receiver operating characteristic (ROC) curve, were 0.905, 0.909, and 0.914, for the different age groups, respectively. 4) The optimal cutoff values for Fres to diagnose airflow obstruction from ROC curves was 17.715 in the COPD patients. Its sensitivity and specificity were 0.789 and 0.931, respectively, and the cutoff values were similar in geriatric and advanced elderly patients.

Conclusion: IOS demonstrated good relevance compared with spirometry for geriatric patients with COPD. IOS may serve as an alternative method for spirometry in elderly subjects for the evaluation of the state of COPD.

Keywords: COPD; geriatric patients; impulse oscillometry; spirometry.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Changes in IOS parameters with increasing airflow limitation. Notes: aP<0.05 compared with the healthy controls. bP<0.05 compared with COPD 1. cP<0.05 compared with COPD 2. Abbreviations: IOS, impulse oscillometry; R5–R20, respiratory resistance; Fres, resonant frequency; X5, respiratory reactance; Z5, respiratory impedance.
Figure 2
Figure 2
ROC curves for COPD in the overall subjects (A), geriatric subjects (B), and advanced elderly subjects (C). Abbreviations: ROC, receiver operating characteristic; X5, respiratory reactance; R5–R20, respiratory resistance; Fres, resonant frequency; Z5, respiratory impedance.
See this image and copyright information in PMC

References

    1. Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012;379(9823):1341–1351. - PMC - PubMed
    1. The Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016. [Accessed March 7, 2017]. Available from: http://goldcopd.org.
    1. Tomalak W, Czajkowska-Malinowska M, Radlinski J. Application of impulse oscillometry in respiratory system evaluation in elderly patients. Pneumonol Alergol Pol. 2014;82(4):330–335. - PubMed
    1. Czajkowska-Malinowska M, Tomalak W, Radlinski J. Quality of spirometry in the elderly. Pneumonol Alergol Pol. 2013;81(6):511–517. - PubMed
    1. Pezzoli L, Giardini G, Consonni S, et al. Quality of spirometric performance in older people. Age Ageing. 2003;32(1):43–46. - PubMed

Publication types

MeSH terms