Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug 12;11(1):242-247.
doi: 10.1515/med-2016-0048. eCollection 2016.

Platelet Rich Plasma: a short overview of certain bioactive components

Voja Pavlovic  1 , Milan Ciric  2 , Vladimir Jovanovic  3 , Predrag Stojanovic  4
Affiliations
Review

Platelet Rich Plasma: a short overview of certain bioactive components

Voja Pavlovic et al. Open Med (Wars). .

Abstract

Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient's own blood and contains different growth factors and other biomolecules necessary for wound healing. Since there are various protocols for PRP preparing, it usually results with PRP generation with different amounts of bioactive substances, which finally may modulate the intensity of wound healing. The reference data about potential effect of some PRP compounds on wound healing, in different tissues, are still controversial. This review summarizes recently known facts about physiological role of certain PRP components and guidance for further research. Also, this review discusses different procedure for PRP generation and potential effect of leukocytes on wound healing.

Keywords: Growth factors; Leukocytes; Platelet rich plasma; Platelets; Wound healing.

PubMed Disclaimer

Conflict of interest statement

Authors state no conflict of interest.

References

    1. Boswell S.G., Cole B.J., Sundman E.A., Karas V., Fortier L.A.. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012;28:429–439. - PubMed
    1. Marques L.F., Stessuk T., Camargo I.C., Sabeh Junior N., dos Santos L., Ribeiro-Paes J.T.. Platelet-rich plasma (PRP): methodological aspects and clinical applications. Platelets. 2015;26:101–113. - PubMed
    1. Foster T.E., Puskas B.L., Mandelbaum B.R., Gerhardt M.B., Rodeo S.A.. Platelet-rich plasma: from basic science to clinical applications. Am. J. Sports Med. 2009;37:2259–2272. - PubMed
    1. Knezevic N.N., Candido K.D., Desai R., Kaye A.D.. Is Platelet-Rich Plasma a Future Therapy in Pain Management? Med. Clin. North Am. 2016;100:199–217. - PubMed
    1. Maynard D.M., Heijnen H.F., Horne M.K., White J.G., Gahl W.A.. Proteomic analysis of platelet alpha-granules using mass spectrometry. J. Thromb. Haemost. 2007;5:1945–1955. - PubMed