Platelet Rich Plasma: a short overview of certain bioactive components

Voja Pavlovic¹, Milan Ciric², Vladimir Jovanovic³, Predrag Stojanovic⁴

Affiliations

¹ Institute of Physiology, Medical Faculty University of Nis, Bulevar Dr. Zorana Djindjica 81, Nis, Serbia.
² Institute of Physiology, Medical Faculty University of Nis, Nis, Serbia.
³ Orthopedic Clinic, Clinical Centre, Nis, Serbia.
⁴ Predrag Stojanovic, Department of Microbiology and Immunology, Nis, Serbia.

PMID: 28352802
PMCID: PMC5329835
DOI: 10.1515/med-2016-0048

Review

Platelet Rich Plasma: a short overview of certain bioactive components

Voja Pavlovic et al. Open Med (Wars). 2016.

. 2016 Aug 12;11(1):242-247.

doi: 10.1515/med-2016-0048. eCollection 2016.

Authors

Voja Pavlovic¹, Milan Ciric², Vladimir Jovanovic³, Predrag Stojanovic⁴

Affiliations

¹ Institute of Physiology, Medical Faculty University of Nis, Bulevar Dr. Zorana Djindjica 81, Nis, Serbia.
² Institute of Physiology, Medical Faculty University of Nis, Nis, Serbia.
³ Orthopedic Clinic, Clinical Centre, Nis, Serbia.
⁴ Predrag Stojanovic, Department of Microbiology and Immunology, Nis, Serbia.

PMID: 28352802
PMCID: PMC5329835
DOI: 10.1515/med-2016-0048

Abstract

Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient's own blood and contains different growth factors and other biomolecules necessary for wound healing. Since there are various protocols for PRP preparing, it usually results with PRP generation with different amounts of bioactive substances, which finally may modulate the intensity of wound healing. The reference data about potential effect of some PRP compounds on wound healing, in different tissues, are still controversial. This review summarizes recently known facts about physiological role of certain PRP components and guidance for further research. Also, this review discusses different procedure for PRP generation and potential effect of leukocytes on wound healing.

Keywords: Growth factors; Leukocytes; Platelet rich plasma; Platelets; Wound healing.

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Conflict of interest statement

Authors state no conflict of interest.

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Platelet Rich Plasma: a short overview of certain bioactive components

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Platelet Rich Plasma: a short overview of certain bioactive components

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