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. 2016 Jul 22;11(1):264-269.
doi: 10.1515/med-2016-0052. eCollection 2016.

Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis

Xiao Haibing  1 , Cao Xu  2 , Cai Jifu  1 , Zeng Wenshuang  1 , Li Ling  1 , Cui Yuzhen  1 , Hu Yanjun  1
Affiliations

Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis

Xiao Haibing et al. Open Med (Wars). .

Abstract

Objective: The aim of this meta-analysis was to undertake a meta-analysis to evaluate the correlation between cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene rs221775 A>G single nucleotide polymorphism and the susceptibility of multiple sclerosis (MS) susceptibility.

Method: Published manuscripts about CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were searched in the computerized bibliographic searches of Pubmed Embase and China National Knowledge Infrastructure (CNKI). Potential studies were screened and data for 5025 MS patients and 4706 controls from 20 publications were included. The association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were demonstrated by odds ratio (OR) and 95% confidence interval (95%CI).

Results: The pooled results showed no significant association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility for dominant genetic model [OR=1.02, 95%CI:0.90~1.05, (P=0.80)], homozygous genetic model [OR=0.85,95%CI:0.71 ~1.03,(P=0.10)] and recessive genetic model [OR=0.99,95% CI:0.89~1.10,(P=0.90)].

Conclusion: With current evidence, CTLA-4 gene rs221775A>G single nucleotide polymorphism had no association with the susceptibility of multiple sclerosis.

Keywords: CTLA-4 gene; Meta-analysis; Multiple sclerosis; Polymorphism; Susceptibility.

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Figures

Figure 1
Figure 1
The forest plot of OR for CTLA-4 gene rs221775 A>G single nucleotide polymorphism and multiple sclerosis susceptibility under dominant model (GG+AG vs AA).
Figure 2
Figure 2
The Begg’s funnel plots showe no significant publication bias under dominant model (GG+AG vs AA)
Figure 3
Figure 3
The forest plot of OR for CTLA-4 gene rs221775 A>G single nucleotide polymorphism and multiple sclerosis susceptibility under homozygous genetic model (GG vs AA).
Figure 4
Figure 4
The Begg’s funnel plots showe no significant publication bias homozygous genetic model (GG vs AA).
Figure 5
Figure 5
The forest plot of OR for CTLA-4 gene rs221775 A>G single nucleotide polymorphism and multiple sclerosis susceptibility under recessive genetic model (GG vs AG+AA)
Figure 6
Figure 6
The Begg’s funnel plots showe no significant publication bias under recessive genetic model(GG vs AG+AA)
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