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Review
. 2016 Aug 13;11(1):292-296.
doi: 10.1515/med-2016-0057. eCollection 2016.

Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia

Li Jianhua  1 , Miao Xueqin  2 , Hu Jifen  1
Affiliations
Review

Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia

Li Jianhua et al. Open Med (Wars). .

Abstract

Objective: To evaluate the expression and correlations of liver X receptor alpha (LXRa) and its target gene sterol regulatory element-binding protein-1c (SREBP-1c) in placentas of preeclampsia (PE) and their significance in PE.

Methods: Pregnancies were divided into two groups, 60 cases (29 cases of mild and 31 cases of severe) of PE group and 56 cases of normal group. The level of mRNA and protein of LXRa and SREBP-1c were analyzed by reverse transcription-polymerase chain reaction (RTPCR) and immunohistochemistry (IHC) in the placentas.

Results: RT-PCR and IHC results showed that the mRNA and protein expression of both LXRa and SREBP-1c increased gradually with the extent of PE among normal pregnancy, mild PE and severe PE groups, and the differences were of statistically significance (P<0.01 or P<0.05). There were positive correlations between the expression of LXRa mRNA and SREBP-1c mRNA, also between LXRa mRNA and LXRa protein (r=0.521, P<0.01; r=0.422, P<0.01). The expression of SREBP-1c mRNA positively correlated with its protein level (r=0.598, P<0.01). There were positive correlations between the expression of LXRa protein and SREBP-1c protein (r=0.612, P<0.01).

Conclusion: The expression of LXRa is elevated significantly in placentas of PE patients, and might contribute for promoting the transcription and translation of its target gene SREBP1-c, which is related to the occurrence and development of PE.

Keywords: LXRa; Preeclampsia; SREBP-1c; Trophoderm.

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Conflict of interest statement

Authors state no conflict of interest

Figures

Figure 1
Figure 1
LXRa mRNA expression in placentas of each group (A: severe PE, B: mild PE, C: normal)
Figure 2
Figure 2
SREBP-1c mRNA expression in placentas of each group (A: severe PE, B: mild PE, C: normal)
Figure 3
Figure 3
The protein of LXRa and SREBP-1c expression in different tissue (A: LXRa protein expression in placenta of a normal pregnancy; B: LXRa protein expression in a mild PE placenta; C: LXRa protein expression in a severe PE placenta; D: SREBP-1c protein expression in placenta of a normal pregnancy; E: SREBP-1c protein expression in a mild PE placenta; F: REBP-1c protein expression in a severe PE placenta)
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