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. 2017:974:245-250.
doi: 10.1007/978-3-319-52479-5_21.

A Clinical Study Protocol to Identify Serum Biomarkers Predictive of Response to Antipsychotics in Schizophrenia Patients

Johann Steiner  1 , Paul C Guest  2
Affiliations

A Clinical Study Protocol to Identify Serum Biomarkers Predictive of Response to Antipsychotics in Schizophrenia Patients

Johann Steiner et al. Adv Exp Med Biol. 2017.

Abstract

An increasing number of studies are now exploring the potential of using blood-based biomarkers for prediction of antipsychotic treatment response in studies of schizophrenia patients. Here we describe the detailed setup of a clinical study to identify biomarker candidates for prediction of response of patients prior to receiving antipsychotics over a 6-week treatment period. The main emphasis is on study design, patient recruitment, sampling and outcome measures.

Keywords: Antipsychotics; Biomarkers; Multiplex immunoassay; PANSS; Proteomics; Schizophrenia; Treatment response.

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