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Review
. 2017 Mar;96(13):e6305.
doi: 10.1097/MD.0000000000006305.

Primary hepatic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type: A case report and literature review

Shuilin Dong  1 , Lin Chen, Yifa Chen, Xiaoping Chen
Affiliations
Review

Primary hepatic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type: A case report and literature review

Shuilin Dong et al. Medicine (Baltimore). 2017 Mar.

Abstract

Rationale: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare disease. To the best of our knowledge, only 67 cases had been reported in 39 English literatures to date. The aim of this study was to add a new case of this disease to the literature and to review the current literature.

Patient concerns: A 50-year-old man was incidentally identified with a solitary mass of 5 cm in diameter in the left lobe of the liver.

Diagnoses: Based on the results of imaging studies, intrahepatic cholangiocellular carcinoma was suspected, and then surgery was performed. Microscopic findings showed that the tumor was a hepatic MALT lymphoma, and immunohistochemical analysis revealed that the lymphoma cells were CD20+, CD79a+, BCL-2+, CD3-, and CD5-.

Interventions: The patient received rituximab after surgery.

Outcomes: He was free of disease for 13 months at the time of this report.

Lessons: Since previously published case reports and our case described nonspecific clinical features of this rare disease, it was usually misdiagnosed before histological confirmation and surgery resection may be a good choice for both diagnosis and local therapy.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Enhanced magnetic resonance imaging findings. The mass was demonstrated low signal intensity on T1-weighted imaging (A) and slightly high signal intensity on T2-weighted imaging (B). The mass was slightly and peripherally enhanced in the arterial phase (C) and portal phase (D).
Figure 2
Figure 2
Gross appearance showed the cut surface of the tumor with a yellow-whitish firm pattern.
Figure 3
Figure 3
Characteristics of histological examination. The lesion consisted of dense lymphocyte infiltration with some lymphoid follicles (A, Hematoxylin and Eosin, HE ×40). Small- to middle-sized, centrocyte-like lymphoid cell population were diffusely infiltrated with lymphoepithelial lesions of bile ducts (B, HE ×200 and C, HE ×400). And lymphocytes were diffusely positive for CD20 (D) and CD79a (E) antibodies. Ki67 labeling index was in a low level (F).
See this image and copyright information in PMC

References

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