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Randomized Controlled Trial
. 2017 Mar;96(13):e6458.
doi: 10.1097/MD.0000000000006458.

Intensive insulin therapy for preventing postoperative infection in patients with traumatic brain injury: A randomized controlled trial

Yan Wang  1 , Jin-Ping Li, Ying-Lun Song, Qi-Huang Zhao
Affiliations
Randomized Controlled Trial

Intensive insulin therapy for preventing postoperative infection in patients with traumatic brain injury: A randomized controlled trial

Yan Wang et al. Medicine (Baltimore). 2017 Mar.

Abstract

Objective: To assess the effect of intensive insulin therapy (IIT) for preventing postoperative infection in patients with traumatic brain injury (TBI).

Methods: In total, 88 patients with TBI were randomly divided into 2 groups, 44 in each group. One group (group ITT) received IIT and the other group (group CIT) received conventional insulin therapy (CIT). This study was conducted between February 2013 and January 2016. Outcomes included infection rate, mortality, and neurological outcome (measured by the Glasgow Outcome Scale [GOS]).

Results: A total of 81 patients completed the study. IIT showed greater efficacy than CIT, with a decreased infection rate in the IIT group compared to the CIT group (31.9% vs 52.3%, P = 0.03), and also a reduced duration of stay in intensive care unit (ICU) (IIT group, 4.5 ± 2.1 days vs CIT group, 5.7 ± 2.8 days, P = 0.02). In addition, a significant difference in scores on the GOS scale was observed between the 2 groups (P = 0.04). The mortality rates in hospital and at the 26-week follow-up were similar between the 2 groups.

Conclusion: IIT leads to a reduced infection rate, shorter stays in ICU, and improved neurological outcome.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart of participants selection.
See this image and copyright information in PMC

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