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. 2016 Jan:39:e228.
doi: 10.1017/S0140525X16000017.

GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena

Mara Mather  1 , David Clewett  2 , Michiko Sakaki  3 , Carolyn W Harley  4
Affiliations

GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena

Mara Mather et al. Behav Brain Sci. 2016 Jan.

Abstract

The GANE (glutamate amplifies noradrenergic effects) model proposes that local glutamate-norepinephrine interactions enable "winner-take-more" effects in perception and memory under arousal. A diverse range of commentaries addressed both the nature of this "hotspot" feedback mechanism and its implications in a variety of psychological domains, inspiring exciting avenues for future research.

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Figures

Fig. R1
Fig. R1
(A) Arousing negative sounds were heard after seeing a background scene either alone or superimposed with a foreground object. (B) The arousing sounds impaired memory for the scene only when it was seen behind the object and, therefore, was somewhat suppressed by that competitor (Ponzio & Mather 2014).
Fig. R2
Fig. R2
Glutamate–NE hot spots originating in the amygdala modulate hippocampal activity via glutamatergic pathways. However, local NE release within the hippocampus also has an impact.
See this image and copyright information in PMC

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