Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May 26;91(12):e00210-17.
doi: 10.1128/JVI.00210-17. Print 2017 Jun 15.

Homologous Capsid Proteins Testify to the Common Ancestry of Retroviruses, Caulimoviruses, Pseudoviruses, and Metaviruses

Mart Krupovic  1 , Eugene V Koonin  2
Affiliations

Homologous Capsid Proteins Testify to the Common Ancestry of Retroviruses, Caulimoviruses, Pseudoviruses, and Metaviruses

Mart Krupovic et al. J Virol. .
No abstract available

Keywords: Caulimoviridae; Metaviridae; Pseudoviridae; Retroviridae; Ty3/Gypsy and Ty1/Copia LTR retrotransposons; nucleocapsid proteins; reverse-transcribing viruses; structural polyprotein Gag; virus evolution.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Multiple-sequence alignment of CAs/CPs of reverse-transcribing viruses belonging to families Retroviridae, Metaviridae, Pseudoviridae, and Caulimoviridae. Representative sequences from all four virus groups were downloaded from the Gypsy Database (23), supplemented with sequences of retroviral CA proteins for which X-ray structures are available, and aligned using PROMALS3D (24). Secondary-structure elements above the alignment are indicated for Rous sarcoma virus CA (PDB accession number 5A9E), which was retrieved as the best match to CPs of metaviruses, pseudoviruses, and caulimoviruses in an HHpred search (data not shown). Red and blue asterisks indicate the conserved residues in the single or tandem Zn-knuckle motifs of the nucleocapsid (NC) domain. Abbreviations: HIV-1, human immunodeficiency virus type 1; BLV, bovine leukemia virus; JSRV, Jaagsiekte sheep retrovirus; LPDV, lymphoproliferative disease virus; MMTV, mouse mammary tumor virus; MPMV, Mason-Pfizer monkey virus; PyERV, Python molurus endogenous retrovirus; EIAV, equine infectious anemia virus; DRM, Danio rerio Mag element; BSGFV, banana streak Goldfinger virus; BSOLV, banana streak OL (badna)virus; CaMV, cauliflower mosaic virus; CERV, carnation etched ring virus; CSSV, cacao swollen-shoot virus; DBV, dasheen bacilliform virus; DrMV, Dracaena mottle virus; MiMV, Mirabilis mosaic virus; TaBV, taro bacilliform virus.
FIG 2
FIG 2
Conservation of the amino acid residues contributing to the stabilization of the hydrophobic core of the α-helical bundles of the CA NTD and CA CTD. Sequence conservation derived from the alignment shown in Fig. 1 was mapped onto the CA structure of Rous sarcoma virus (PDB accession number 5A9E). The least conserved regions are red, whereas those most conserved are in blue.
See this image and copyright information in PMC

References

    1. Koonin EV, Dolja VV, Krupovic M. 2015. Origins and evolution of viruses of eukaryotes: the ultimate modularity. Virology 479-480:2–25. doi: 10.1016/j.virol.2015.02.039. - DOI - PMC - PubMed
    1. King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ. 2011. Virus taxonomy. Ninth report of the International Committee on Taxonomy of Viruses. Elsevier Academic, London, United Kingdom.
    1. Palmer KJ, Tichelaar W, Myers N, Burns NR, Butcher SJ, Kingsman AJ, Fuller SD, Saibil HR. 1997. Cryo-electron microscopy structure of yeast Ty retrotransposon virus-like particles. J Virol 71:6863–6868. - PMC - PubMed
    1. Gladyshev EA, Arkhipova IR. 2011. A widespread class of reverse transcriptase-related cellular genes. Proc Natl Acad Sci U S A 108:20311–20316. doi: 10.1073/pnas.1100266108. - DOI - PMC - PubMed
    1. Krupovic M, Bamford DH. 2010. Order to the viral universe. J Virol 84:12476–12479. doi: 10.1128/JVI.01489-10. - DOI - PMC - PubMed

Publication types

LinkOut - more resources