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. 1988 Mar;8(3):1380-4.
doi: 10.1128/mcb.8.3.1380-1384.1988.

Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation

V Cherington  1 , M Brown, E Paucha, J St Louis, B M Spiegelman, T M Roberts
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Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation

V Cherington et al. Mol Cell Biol. 1988 Mar.

Abstract

Wild-type simian virus 40 large T antigen is very effective at blocking adipocyte differentiation in 3T3-F442A cells as assayed by triglyceride accumulation, induction of glycerophosphate dehydrogenase activity, and expression of mRNAs for glycerophosphate dehydrogenase, the adipocyte serine protease adipsin, and the putative lipid-binding protein adipocyte P2. Point mutants defective for either origin-specific DNA binding or transformation blocked differentiation as completely as wild type.

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