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. 2015 Apr;34(2):228-232.
doi: 10.2478/jomb-2014-0028. Epub 2015 Mar 3.

Laryngeal Granuloma - Benefit in Treatment with Zinc Supplementation?

Vojko Djukić  1 , Sanja Krejović-Trivić  1 , Milan Vukašinović  1 , Aleksandar Trivić  1 , Bojan Pavlović  1 , Aleksandar Milovanović  2 , Jovica Milovanović  1
Affiliations

Laryngeal Granuloma - Benefit in Treatment with Zinc Supplementation?

Vojko Djukić et al. J Med Biochem. 2015 Apr.

Abstract
in English, Serbian

Laryngeal granulomas present as contact and postintubation ulcers and granulomas. Essentially, a contact granuloma is a pseudotumor of the lateral wall of the posterior glottis. The most common etiological factor is voice abuse, with predisponing factors such as reflux disease. Postintubation ulcers and granulomas, although of different etiology, according to all the other traits belong to this clinical entity. The therapy of choice is conservative treatment. Surgical laser excision is indicated for resistant cases and those whose size is causing respiratory distress. Treatment of laryngeal granulomas with zinc supplementation is reported in the literature as one of the forms of conservative treatment, and we wanted to consider it in this review. Zinc is an essential mineral that plays a vital role in many biochemical reactions and is considered very important for wound healing.

Larinksni granulom se predstavlja kontaktnim i postintubacionim ulkusom i granulomom. U suštini, kontaktni granulom je pseudotumorski izraštaj lateralnog zida zadnjeg dela glotisa. Najčešći etiološki faktor je neodgovarajuća upotreba glasa, uz predisponirajuće faktore kao što je refluksna bolest. Postintubacioni ulkus i granulom, iako drugačije etiologije, po svim ostalim osobinama pripadaju ovom kliničkom entitetu. Preporučena terapija je konzervativno lečenje, a hirurška laserska ekscizija indikovana je za rezistentne slučajeve i one koji svojom veličinom izazivaju respiratorne smetnje. U literaturi se pominje peroralna primena preparata cinka u terapiji larinksnog granuloma kao jedan od vidova konzervativnog lečenja, što smo i mi u ovom kratkom pregledu želeli da razmotrimo. Cink je esencijalni mineral koji igra ključnu ulogu u mnogim biohemijskim reakcijama i smatra se da je veoma važan za zarastanje rana.

Keywords: conservative treatment; laryngeal granuloma; zinc supplementation.

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Figures

Figure 1
Figure 1
Endoscopic findings: typical appearance of a post-intubation granuloma of the vocal cord.
Figure 2
Figure 2
Histopathological findings of laryngeal granuloma.
See this image and copyright information in PMC

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