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. 2015 Oct;34(4):431-439.
doi: 10.1515/jomb-2015-0002. Epub 2015 Sep 19.

Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?

Dragan Djordjevic  1 , Janko Pejovic  2 , Maja Surbatovic  1 , Jasna Jevdjic  3 , Sonja Radakovic  4 , Milic Veljovic  1 , Aneta Peric  5 , Tamara Andjelic  6 , Nada Popovic  7
Affiliations

Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?

Dragan Djordjevic et al. J Med Biochem. 2015 Oct.

Abstract
in English, Serbian

Background: Severe sepsis and/or trauma complicated by multiple organ dysfunction syndrome are the leading causes of death in critically ill patients. The aim of this prospective single-centre study was to assess the prognostic value and daily trend of interleukin-6 (IL-6), neutrophil CD64 expression, C-reactive protein (CRP) and lipopolysaccharide-binding protein (LBP) regarding outcome in critically ill patients with severe trauma and/or severe sepsis. Outcome measure was hospital mortality.

Methods: One hundred and two critically ill patients admitted to the intensive care unit of a tertiary university hospital were enrolled in this prospective study. Blood samples were collected on admission (day 1), days 2 and 3.

Results: CD64 index was 1.6-fold higher on day 1 and 1.78-fold higher on day 2 in non-survivors (p<0.05). The area under the curve (AUC) for the CD64 index on day 1 for outcome was 0.727. At a cut-off level of 2.80 sensitivity was 75% and specificity was 65%. Patients with CD64 index level on day 1 higher than 2.80 had 2.4-fold higher probability of dying. Odds ratio is 2.40; 95% CI 0.60-9.67.

Conclusions: CD64 index on day 1 is a fairly good predictor of outcome. AUCs for IL-6, CRP and LBP were < 0.55, suggesting these biomarkers failed to predict outcome.

Uvod: Teška sepsa i/ili trauma kod koje se kao komplikacija javlja sindrom multiple organske disfunkcije je vodeći uzrok smrti kod kritično obolelih. Cilj ove prospektivne studije je bio da se proceni prognostička vrednost i utvrdi kinetika inter-leukina-6 (IL-6), ekspresije CD64 na neutrofilima, C-reaktivnog proteina (CRP) i proteina koji vezuje lipopolisaharid (lipopolysaccharide-binding protein – LBP) u smislu ishoda kod kritično obolelih sa teškom traumom i/ili teškom sepsom. Mera ishoda je bio hospitalni mortalitet.

Metode: Sto dva kritično obolela pacijenta primljena u jedini-cu intenzivne terapije tercijarne univerzitetske bolnice su obu-hvaćena prospektivnom studijom. Uzorci krvi su sakupljani na dan prijema (dan 1), a zatim drugog i trećeg dana.

Rezultati: CD64 indeks je bio 1,6 puta viši prvog dana i 1,78 puta viši drugog dana kod umrlih (p<0,05). Vrednost AUC/ROC za CD64 indeks prvog dana u smislu predikcije ishoda je bila 0,727. Pri cut-off vrednosti od 2,80 senzitivnost je bila 75%, specifičnost 65% a OR 2,40 (95% CI 0,60–9,67). Pacijenti sa nivoom CD64 indeksa prvog dana višim od 2,80 imali su 2,4 puta veću verovatnoću smrtnog ishoda.

Zaključak: Vrednost CD64 indeksa prvog dana je dobar prediktor ishoda. AUC/ROC vrednosti za IL-6, CRP i LBP su bile < 0,55, pa se ovi biomarkeri nisu pokazali dobrim pre-diktorima ishoda.

Keywords: biomarkers; critical care; leukocytes; outcome; prognosis.

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Figures

Figure 1
Figure 1
Receiver operator curve for the CD64 index levels on day 1.
Figure 2
Figure 2
Values of IL-6 from day 1 to day 3 according to outcome.
Figure 3
Figure 3
Values of CD64 index from day 1 to day 3 according to outcome.
Figure 4
Figure 4
Values of CRP from day 1 to day 3 according to outcome.
Figure 5
Figure 5
Values of LBP from day 1 to day 3 according to outcome.
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