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. 1988 Feb;2(3):285-91.

Amplification of the int-2 gene in primary human breast tumors

R Lidereau  1 , R Callahan, C Dickson, G Peters, C Escot, I U Ali
Affiliations
  • PMID: 2835739

Amplification of the int-2 gene in primary human breast tumors

R Lidereau et al. Oncogene Res. 1988 Feb.

Abstract

Proviral activation of the int-2 gene is a frequent occurrence in mammary carcinomas induced by mouse mammary tumor virus (MMTV). Here, we have examined the human homolog of int-2 in 110 primary breast cancer DNAs. The locus was amplified 2- to 15-fold in 18 of the tumor DNA samples. Amplification of int-2 has a highly significant association (P less than 2 X 10(-6] with tumors from patients who subsequently developed a local recurrence of the disease or a distal metastasis.

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