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Comment
. 2017 Mar 2;4(3):105-107.
doi: 10.15698/mic2017.03.565.

Advancing host-directed therapy for tuberculosis

Chul-Su Yang  1
Affiliations
Comment

Advancing host-directed therapy for tuberculosis

Chul-Su Yang. Microb Cell. .

Abstract

Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasite Toxoplasma gondii (T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of Mycobacterium tuberculosis (MTB).

Keywords: Mycobacterium tuberculosis; Toxoplasma gondii GRA7; macrophages; protein-protein interactions.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1. FIGURE 1: Summary of the interactions of GRA7 and its mutants with ASC, PLD1, TRAF6, and PKCα.
Figure 2
Figure 2. FIGURE 2: Advancing host-directed therapy for tuberculosis: new therapeutic insights from the T. gondii GRA7.
Schematic model for the roles of GRA7 and GRA7-mediated regulatory pathways against intracellular pathogens such as Mycobacteria and T. gondii.
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