Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;19(4):31.
doi: 10.1007/s11936-017-0527-5.

Targeting Frailty in Heart Failure

Susan M Joseph  1 , Michael W Rich  2
Affiliations
Review

Targeting Frailty in Heart Failure

Susan M Joseph et al. Curr Treat Options Cardiovasc Med. 2017 Apr.

Abstract

Frailty is a systemic syndrome characterized by impaired physiologic reserve, slowness, weakness, and wasting. It is associated with, but distinct from, aging, disability, and multimorbidity. Frailty is extremely common in patients with heart failure and portends a worse prognosis. The two syndromes worsen one another via complex molecular and cellular mechanisms which are not fully understood but include increased levels of stress hormones and cytokines. In this article, we discuss the mechanisms of frailty and review common frailty metrics. We review and summarize the literature on the impact of frailty in heart failure and discuss treatment and management options.

Keywords: Frailty; Fried criteria; Heart failure; Multimorbidity; Sarcopenia.

PubMed Disclaimer

References

    1. J Vasc Surg. 2011 Apr;53(4):912-7 - PubMed
    1. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56 - PubMed
    1. J Heart Lung Transplant. 2014 Apr;33(4):359-65 - PubMed
    1. Circulation. 2010 Jan 19;121(2):214-20 - PubMed
    1. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003288 - PubMed

LinkOut - more resources