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Review
. 2017 Jun;6(2):213-223.
doi: 10.1007/s40121-017-0154-1. Epub 2017 Mar 29.

A Review of Diagnostic Methods for Invasive Fungal Diseases: Challenges and Perspectives

Diego R Falci  1   2 , Claudio M B Stadnik  3   4 , Alessandro C Pasqualotto  5   6
Affiliations
Review

A Review of Diagnostic Methods for Invasive Fungal Diseases: Challenges and Perspectives

Diego R Falci et al. Infect Dis Ther. 2017 Jun.

Abstract

Invasive fungal diseases are associated with a high morbidity and mortality, particularly in the context of immunosuppression. Diagnosis of invasive fungal diseases is usually complicated by factors such as poor clinical suspicion and unspecific clinical findings. Access to modern diagnostic tools is frequently limited in developing countries. Here, we describe five real-life clinical cases from a Brazilian tertiary hospital, in order to illustrate how to best select diagnostic tests in patients with different fungal infections.

Keywords: Antigen detection; Beta-D-glucan; Galactomannan; MALDI-TOF; PCR.

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Figures

Fig. 1
Fig. 1
Magnetic resonance imaging of the thorax, demonstrating bilateral pulmonary nodules (Case 1)
Fig. 2
Fig. 2
Computerized tomography of the thorax, showing multiple pulmonary nodules and patchy infiltrates (Case 2)
See this image and copyright information in PMC

References

    1. Kauffman CA, Freifeld AG, Andes DR, Baddley JW, Herwaldt L, Walker RC, et al. Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET) Transpl Infect Dis. 2014;16(2):213–224. doi: 10.1111/tid.12186. - DOI - PMC - PubMed
    1. Benedict K, Derado G, Mody RK. Histoplasmosis-associated hospitalizations in the United States, 2001–2012. Open Forum Infect Dis. 2016;3(1):ofv219. doi: 10.1093/ofid/ofv219. - DOI - PMC - PubMed
    1. Cunha VS, Zampese MS, Aquino VR, Cestari TF, Goldani LZ. Mucocutaneous manifestations of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome: particular aspects in a Latin–American population. Clin Exp Dermatol. 2007;32(3):250–255. doi: 10.1111/j.1365-2230.2007.02392.x. - DOI - PubMed
    1. Freifeld AG, Iwen PC, Lesiak BL, Gilroy RK, Stevens RB, Kalil AC. Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center. Transpl Infect Dis. 2005;7(3–4):109–115. doi: 10.1111/j.1467-8365.2005.00105.x. - DOI - PubMed
    1. Goldani LZ, Aquino VR, Lunardi LW, Cunha VS, Santos RP. Two specific strains of Histoplasma capsulatum causing mucocutaneous manifestations of histoplasmosis: preliminary analysis of a frequent manifestation of histoplasmosis in southern Brazil. Mycopathologia. 2009;167(4):181–186. doi: 10.1007/s11046-008-9171-7. - DOI - PubMed

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