Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

Stephanie Fanucchi¹, Musa M Mhlanga²

Affiliations

¹ Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: parrucchiere@mhlangalab.org.
² Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: yoda@mhlangalab.org.

PMID: 28359583
DOI: 10.1016/j.tig.2017.03.004

Comment

Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

Stephanie Fanucchi et al. Trends Genet. 2017 Jun.

. 2017 Jun;33(6):375-377.

doi: 10.1016/j.tig.2017.03.004. Epub 2017 Mar 27.

Authors

Stephanie Fanucchi¹, Musa M Mhlanga²

Affiliations

¹ Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: parrucchiere@mhlangalab.org.
² Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: yoda@mhlangalab.org.

PMID: 28359583
DOI: 10.1016/j.tig.2017.03.004

Abstract

How does the non-coding portion of the genome contribute to the regulation of genome architecture? A recent paper by Tan et al. focuses on the relationship between cis-acting complex-trait-associated lincRNAs and the formation of chromosomal contacts in topologically associating domains (TADs).

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cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture.
Tan JY, Smith AAT, Ferreira da Silva M, Matthey-Doret C, Rueedi R, Sönmez R, Ding D, Kutalik Z, Bergmann S, Marques AC. Tan JY, et al. Cell Rep. 2017 Feb 28;18(9):2280-2288. doi: 10.1016/j.celrep.2017.02.009. Cell Rep. 2017. PMID: 28249171

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Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

Affiliations

Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

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Abstract

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