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. 2017 Mar-Apr;34(2):138-143.
doi: 10.4103/0970-2113.201299.

Study the association of chronic obstructive pulmonary disease with early endothelial dysfunction and its impact on cardiovascular system by estimating urinary albumin creatinine ratio

Anand Agrawal  1 , Renu Garg  2 , Dibakar Sahu  1 , Mukesh Kumar  3
Affiliations

Study the association of chronic obstructive pulmonary disease with early endothelial dysfunction and its impact on cardiovascular system by estimating urinary albumin creatinine ratio

Anand Agrawal et al. Lung India. 2017 Mar-Apr.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) attribute to systemic inflammation which is responsible for microalbuminuria reflecting endothelial dysfunction, could be a significant surrogate marker of potential cardiovascular morbidity.

Objective: The aim of our study was to find out the possible association of COPD with early cardiovascular changes in the form of renal endothelial dysfunction.

Settings and design: Case-control, multi-group, cross-sectional hospital-based study was designed and conducted in the Department of Respiratory Medicine of BPS Government Medical College for Women, Khanpur Kalan, Sonipat, Haryana.

Subjects and methods: The study included 150 subjects, comprising of three groups with each having 50 subjects: Group 1 - acute exacerbation of COPD, Group 2 - stable COPD patients, Group 3 - asymptomatic smokers. Pulmonary function test, urine albumin creatinine ratio (UACR) and brachio-ankle pulse wave velocity were measured in all the subjects.

Statistical analysis: Data were analyzed using SPSS ver 20 (IBM, USA) software. Continuous variables were compared by unpaired Student's t-test while correlation was measured by Pearson correlation test, P < 0.05 was considered statistically significant.

Results: The mean urine albumin creatinine ratio UACR value in acute exacerbation of COPD (283.30 mg/g; standard deviation [SD] ±871.98) was found significantly higher compare to control subjects (24.17 mg/g; SD ± 32.105;) P = 0.038. Besides this COPD patients with Type 2 respiratory failure having robust positive correlation in between UACR and arterial blood pH (r = 0.559; P = 0.030) while it was inverse and moderate with partial pressure of arterial oxygen (r = -0.470; P = 0.077).

Conclusions: Acute state of COPD with or without Type 2 respiratory failure is having a significant impact on cardiovascular system in the form of early microvascular changes.

Keywords: Endothelium; inflammation; lung; microvascular; obstructive diseases.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Graphical presentation of urine albumin creatinine ratio level and its component among various study groups
Figure 2
Figure 2
Scattered plot showing correlation of urine albumin creatinine ratio with blood pH in acute exacerbation of chronic obstructive pulmonary disease
See this image and copyright information in PMC

References

    1. Raherison C, Girodet PO. Epidemiology of COPD. Eur Respir Rev. 2009;18:213–21. - PubMed
    1. Vijayan VK. Chronic obstructive pulmonary disease. Indian J Med Res. 2013;137:251–69. - PMC - PubMed
    1. Asche CV, Leader S, Plauschinat C, Raparla S, Yan M, Ye X, et al. Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids. Int J Chron Obstruct Pulmon Dis. 2012;7:201–9. - PMC - PubMed
    1. Fabbri LM, Luppi F, Beghé B, Rabe KF. Complex chronic comorbidities of COPD. Eur Respir J. 2008;31:204–12. - PubMed
    1. Hansell AL, Walk JA, Soriano JB. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis. Eur Respir J. 2003;22:809–14. - PubMed