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. 2017 Mar 17:12:931-936.
doi: 10.2147/COPD.S131246. eCollection 2017.

Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

Yipeng Ding  1 , Heping Xu  1 , Jinjian Yao  1 , Dongchuan Xu  1 , Ping He  1 , Shengyang Yi  1 , Quanni Li  1 , Yuanshui Liu  1 , Cibing Wu  1 , Zhongjie Tian  1
Affiliations

Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

Yipeng Ding et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Objective: We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population.

Methods: In a case-control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender.

Results: In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10-0.82; P=0.02). In the genetic model analysis, we found that the "C/C" genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13-0.86; P=0.022) and recessive model (OR =0.32; 95% CI =0.12-0.80; P=0.009).

Conclusion: Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population.

Keywords: COPD; RTEL1; association study; case-control study; chronic obstructive pulmonary disease; gene polymorphisms.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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