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Review
. 2017 Mar 20:9:177-183.
doi: 10.2147/BCTT.S127583. eCollection 2017.

Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?

Tabitha Y Chan  1 , Poh Wee Tan  1 , Johann I Tang  1
Affiliations
Review

Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?

Tabitha Y Chan et al. Breast Cancer (Dove Med Press). .

Abstract

Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer. Dosimetry planning for conventional WBEBRT typically involves a pair of tangential fields. Advancement in radiation technology and techniques has the potential to improve treatment outcomes with clinically meaningful long-term benefits. However, this advancement must be balanced with safety and improved efficacy. Intensity-modulated radiation therapy (IMRT) is an advanced technique that shows promise in improving the planning process and radiation delivery. Early data on utilizing IMRT for WBEBRT demonstrate more homogenous dose distribution with reduction in organs at risk doses. This translates to toxicities reduction. The two common descriptors for IMRT are forward-planning "fields in field" and inverse planning. Unlike IMRT for other organs, the aim of IMRT for breast planning is to achieve dose homogeneity and not organ conformality. The aim of this paper was to evaluate whether IMRT is ready for prime time based on these three points: 1) workload impact, 2) the clinical impact on the patient's quality of life, and 3) the appropriateness and applicability to clinical practice.

Keywords: clinical practice; early-stage breast cancer; intensity-modulated radiation therapy; quality of life; radiotherapy; workload impact.

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Conflict of interest statement

Disclosure The authors report no funding sources and no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Forward-planning “field in field” IMRT technique. A and C demonstrate tangent fields without shielding. B and D demonstrate tangent fields that shielded the volumes receiving ≥110% of the prescribed dose using multileaf collimator. Abbreviation: IMRT, intensity-modulated radiation therapy.
See this image and copyright information in PMC

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