Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec;51(4):395-400.
doi: 10.5152/npa.2014.7213. Epub 2014 Dec 1.

The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients

Özlem Selçuk  1 , Vildan Yayla  2 , Murat Çabalar  2 , Vildan Güzel  3 , Samiye Uysal  2 , Asuman Gedikbaşi  4
Affiliations

The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients

Özlem Selçuk et al. Noro Psikiyatr Ars. 2014 Dec.

Abstract

Introduction: S100B protein, which helps nerve development and differentiation, is produced by astrocytes and can be detected in peripheral circulation after brain damage. In this study, we aimed to investigate the relationship between the serum S100B protein level and the infarction volume and clinical outcome and also the early prognostic role of serum S100B protein in patients with ischemic stroke.

Method: Fifty patients admitted in the first 24-hour period of acute ischemic stroke were evaluated prospectively, and the findings were compared to those of the controls (n=26). S100B levels of the patients and neurological findings on days 1, 3, and 5 and their functional outcomes on the discharge day and at the first month were recorded by the same examiner.

Results: S100B levels were not affected by sex, age, or concomitant systemic diseases. The maximum levels of S100B were recorded on the 3rd day, and there was a correlation between infarct size and S100B levels. No correlation between the severity of stroke and S100B level was found. There was a poor correlation between the functional outcomes of the patients at the 1st month and S100B levels and on the 3rd day.

Conclusion: The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients.

Keywords: Brain; biological markers; cerebrovascular disorders; prognosis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors reported no conflict of interest related to this article.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hankey GJ. Stroke how large a public health problem and how can the neurologist help? Arch Neurol. 1999;56:748–754. http://dx.doi.org/10.1001/archneur.56.6.748. - DOI - PubMed
    1. Yalçın A. Stroke risk in elderly individuals: Novel molecules in stroke&therapeutical targets. Turkiye klinikleri J Med Sci. 2009;29:72–75.
    1. Murray CJ, Lopez AD. global mortality, disability the contribution of risk factor: Global burder of the disease study. Lancet. 1997;349:1436–1442. http://dx.doi.org/10.1016/S0140-6736%2896%2907495-8. - DOI - PubMed
    1. Dönder E, Özkan Y, Gençer V, Baydaş G. The effect of experimentally induced maternal hypotyroidism on gfap and S100B protein expression in fetal brain tissue on tenth and fifteenth gestational days in newborn period. Turkiye klinikleri J Med Sci. 2010;30:462–468. http://dx.doi.org/10.5336/medsci.2008-8325. - DOI
    1. Kaca-Orynska M, Tomasiuk R, Friedman A. Neuron-specific enolase and S100B protein as predictors of outcome in ischaemic stroke. neurol neurochir pol. 2010;44:459–463. - PubMed

LinkOut - more resources