Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec;53(4):328-333.
doi: 10.5152/npa.2016.11327. Epub 2016 Dec 1.

Symptomatic Remission Determines Functional Improvement and Quality of Life in Schizophrenia

Mehmet Hanifi Kokaçya  1 , Osman Virit  2 , Ümit Sertan Çöpoğlu  2 , Haluk Savaş  2 , Mustafa Ari  1 , Bülent Bahçeci  3
Affiliations

Symptomatic Remission Determines Functional Improvement and Quality of Life in Schizophrenia

Mehmet Hanifi Kokaçya et al. Noro Psikiyatr Ars. 2016 Dec.

Abstract

Introduction: Schizophrenia is a chronic illness that negatively affects the quality of life and psychosocial functions. Defined criteria to assess remission in schizophrenia are considered to be useful in the long-term follow-up of patients and in discriminating diagnostic factors. This study investigated the quality of life and functionality in schizophrenia patients in symptomatic remission (R-Sch) and not in remission (Non-R-Sch).

Methods: Sociodemographic data were collected for 40 R-Sch and 40 Non-R-Sch patients, and the following scales were administered: the Clinical Global Impression-Severity (CGI-S) Scale; Positive and Negative Syndrome Scale (PANSS), World Health Organization Quality of Life Questionnaire-Short Form, Turkish Version (WHOQOL-BREF-TR), Quality of Life Scale for Schizophrenia Patients (QLS), and Global Assessment of Functioning Scale (GAF).

Results: The total and all subscale scores of PANSS and the CGI-S score were significantly lower in the R-Sch group than in the Non-R-Sch group, whereas the GAF scores and all subscales of QLS and WHOQOL-BREF-TR were significantly higher.

Conclusion: This study demonstrates that improvement in symptoms in schizophrenia patients improves quality and functionality in all areas of life, suggesting that an improvement in symptoms is the most important determinant of functional recovery in the treatment of schizophrenia.

Keywords: Schizophrenia; quality of life; symptomatic remission.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

References

    1. Tarbox SI, Addington J, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Heinsenn R, McGlashan TH, Woods SW. Functional development in clinical high risk youth: Prediction of schizophrenia versus other psychotic disorders. Psychiatry Res. 2014;215:52–60. https://doi.org/10.1016/j.psychres.2013.10.006. - DOI - PMC - PubMed
    1. Eren İ, Şimşek D, Çalışkan AM. Şizofreni hastalarında yetiyitimi ve belirti şiddetinin yaşam kalitesine etkisi. Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi. 2007;20:68–78.
    1. Andreasen NC, Carpenter WT, Kane JM, Lasser RA, Marder SR, Weinberger DR. Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. 2005;162:441–449. https://doi.org/10.1176/appi.ajp.162.3.441. - DOI - PubMed
    1. Fan X, Henderson DC, Nguyen DD, Cather C, Freudenreich O, Evins AE, Borba C, Goff DC. Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia. Psychiatry Res. 2008;159:140–146. https://doi.org/10.1016/j.psychres.2007.10.012. - DOI - PubMed
    1. Priebe S, McCabe R, Junghan U, Kallert T, Ruggeri M, Slade M, Reininghaus U. Association between symptoms and quality of life in patients with schizophrenia: a pooled analysis of changes over time. Schizophr Res. 2011;133:17–21. https://doi.org/10.1016/j.schres.2011.09.021. - DOI - PubMed

LinkOut - more resources