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. 1985;9(5):373-82.
doi: 10.1007/BF00421608.

The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina

U Kück  1 , H D Osiewacz, U Schmidt, B Kappelhoff, E Schulte, U Stahl, K Esser
Affiliations

The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina

U Kück et al. Curr Genet. 1985.

Abstract

Mapping and transcription studies have revealed that in Podospora anserina the causative agent of senescence, a mitochondrial plasmid (plDNA), is identical with intron 1 of the discontinuous gene for cytochrome-c-oxidase subunit 1 (COI), which is 2 kpb from the discontinuous gene for cytochrome b (Cytb). A mitochondrial mutant (ex1) devoid of the COI, but not of the Cytb gene provides longevity. A molecular model for the onset of senescence is presented.

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References

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