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. 2017 Mar-Apr;11(3-4):E100-E104.
doi: 10.5489/cuaj.4016. Epub 2017 Mar 16.

Is testis-sparing surgery safe in small testicular masses? Results of a multicentre study

Murat Keske  1 , Abdullah Erdem Canda  2 , Serdar Yalcin  3 , Aydan Kilicarslan  1 , Yusuf Kibar  3 , Can Tuygun  4 , Evrim Onder  4 , Ali Fuat Atmaca  2 , Asif Yildirim  5 , Sidika Seyma Ozkanli  5 , Olcay Kandemir  6 , Taner Kargi  7 , Mehmet Sar  7 , Volkan Tugcu  7 , Berkan Resorlu  1 , Yilmaz Aslan  8 , Selcuk Sarikaya  9 , Ugur Boylu  10 , Ali Fuat Cicek  3 , Halil Basar  6 , Altug Tuncel  8 , Mevlana Derya Balbay  11
Affiliations

Is testis-sparing surgery safe in small testicular masses? Results of a multicentre study

Murat Keske et al. Can Urol Assoc J. 2017 Mar-Apr.

Abstract

Introduction: Our goal was to evaluate benign and malignant lesions and testicular intraepithelial neoplasia (TIN) in the neighbouring normal-appearing testis tissue in men who underwent radical orchiectomy for testicular mass with a pathologic tumour size of ≤3cm.

Methods: In this retrospective, multicentre study, data of 252 patients from 11 different institutions were included. Patients were divided into three groups based on tumour size: Group 1 (0-1 cm; n=35), Group 2 (1.1-2cm; n=99), and Group 3 (2.1-3 cm; n=118). Benign lesions and TIN were sought in the neighbouring testicular tissue and compared between groups.

Results: Mean patient age was 32.3 years. Benign lesions were reported in 54.3%, 33.3%, and 14.4% of Groups 1, 2, and 3, respectively (p<0.05 between groups). TIN was detected in 20%, 42.4%, and 41.5% of Groups 1, 2, and 3, respectively (p<0.05 for Group 1 vs. Groups 2 and 3; p>0.05 for Groups 2 vs. 3). Multifocality was detected in 8.6%, 4%, and 0% of Groups 1, 2, and 3, respectively (p<0.05 for both Group 1 vs. Group 3 and for Group 2 vs. Group 3; p>0.05 for Group 1 vs. Group 2). A tumour cutoff size of 1.5 cm was found to be significant for detecting benign tumour. TIN and multifocality rates were similar in patients with a tumour size of ≤1.5 vs. >1.5 cm (p>0.05).

Conclusions: Benign lesions and TIN in the neighbouring testis were significantly decreased and multifocality was increased in patients with a tumour mass size of ≤1 cm. Testis-sparing surgery should be performed with caution and a safety rim of normal tissue should also be excised.

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Figures

Fig. 1
Fig. 1
Percentage of benign and malignant testicular tumours, testicular intraepithelial neoplasia (TIN) and multifocality in the neighbouring testis tissue (Group 1: tumour size ≤1 cm; Group 2: tumour size 1.1–2.0 cm; Group 3: tumour size 2.1–3.0 cm). P values for detecting benign and malignant testicular mass lesions between groups include Group 1 vs. Group 2, p=0.047; Group 1 vs. Group 3, p=0.000; and Group 2 vs. Group 3, p=0.002. P values for detecting TIN between groups include Group 1 vs. Group 2, p=0.031; Group 1 vs. Group 3, p=0.034; and Group 2 vs. Group 3, p=0.894. P values for detecting multifocality between groups include Group 1 vs. Group 2, p=0.337; Group 1 vs. Group 3, p=0.011; and Group 2 vs. Group3, p=0.042.
Fig. 2
Fig. 2
Percentage of benign, malignant testicular tumours, testicular intraepithelial neoplasia (TIN) and multifocality in the neighbouring testis tissue due to a tumour cutoff size of 1.5 cm (Group A: tumor size ≤1.5 cm; Group B: tumour size 1.6–3.0 cm). P values for detecting benign and malignant testicular mass lesions between groups include Group A vs. Group B, p=0.000. P values for detecting TIN between groups include Group A vs. Group B, p=0.069. P values for detecting multifocality between groups include Group A vs. Group B, p=0.012.
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References

    1. La Vecchia C, Bosetti C, Lucchini F, et al. Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975. Ann Oncol. 2010;21:1323–60. https://doi.org/10.1093/annonc/mdp530. - DOI - PubMed
    1. Engholm G, Ferlay J, Christensen N, et al. NORDCAN—a Nordic tool for cancer information, planning, quality control, and research. Acta Oncol. 2010;49:725–36. https://doi.org/10.3109/02841861003782017. - DOI - PubMed
    1. Klatte T, de Martino M, Arensmeier K, et al. Management and outcome of bilateral testicular germ cell tumours: A 25-year, single-centre experience. Int J Urol. 2008;15:821–6. https://doi.org/10.1111/j.1442-2042.2008.02107.x. - DOI - PubMed
    1. Heidenreich A, Weissbach L, Höltl W, et al. German Testicular Cancer Study Group. Organ-sparing surgery for malignant germ cell tumour of the testis. J Urol. 2001;166:2161–5. https://doi.org/10.1016/S0022-5347(05)65526-7. - DOI - PubMed
    1. Albers P, Albrecht W, Algaba F, et al. Guidelines on testicular cancer: 2015 update. Eur Urol. 2015;68:1054–68. https://doi.org/10.1016/j.eururo.2015.07.044. - DOI - PubMed

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