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Review
. 2017 Jun;32(3):651-665.
doi: 10.1007/s11011-017-9997-0. Epub 2017 Mar 30.

The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone

Shima Motamedi  1 , Isaac Karimi  2 , Fariba Jafari  3
Affiliations
Review

The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone

Shima Motamedi et al. Metab Brain Dis. 2017 Jun.

Abstract

The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.

Keywords: BDNF; Depression; Metabolic syndrome; Neurodegenerative diseases; Obesity.

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References

    1. Brain Circ. 2015;1(1):69-78 - PubMed
    1. J Hum Hypertens. 2015 Jan;29(1):33-9 - PubMed
    1. Int J Med Sci. 2016 Jan 01;13(1):25-38 - PubMed
    1. Eur J Endocrinol. 2007 Sep;157(3):303-10 - PubMed
    1. Int J Pept. 2011;2011:654085 - PubMed

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