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. 2017 Mar;162(5):671-675.
doi: 10.1007/s10517-017-3684-3. Epub 2017 Mar 30.

Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings

S G Kalinichenko  1   2 , N Yu Matveeva  3   4 , R E Kostiv  3 , A V Puz'  4
Affiliations

Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings

S G Kalinichenko et al. Bull Exp Biol Med. 2017 Mar.

Abstract

The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.

Keywords: bioactive nanoscale materials; bone tissue remodeling; morphogenetic factors.

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