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Comment
. 2017 Mar 31;19(4):261-263.
doi: 10.1038/ncb3494.

Demystifying blood stem cell fates

Fiona K Hamey  1 , Berthold Göttgens  1
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Free article
Comment

Demystifying blood stem cell fates

Fiona K Hamey et al. Nat Cell Biol. .
Free article

Abstract

Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

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  • Human haematopoietic stem cell lineage commitment is a continuous process.
    Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM. Velten L, et al. Nat Cell Biol. 2017 Apr;19(4):271-281. doi: 10.1038/ncb3493. Epub 2017 Mar 20. Nat Cell Biol. 2017. PMID: 28319093 Free PMC article.

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