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Randomized Controlled Trial
. 2017 Mar 31:7:45628.
doi: 10.1038/srep45628.

PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study

Chun-Chung Chen  1   2   3 , XianXiu Chen  3   4 , Tsai-Chung Li  5 , Hung-Lin Lin  2 , Yen-Tze Chu  6 , Han-Chung Lee  1   2 , Yu-Kai Cheng  2 , Der-Cherng Chen  2 , Shiu-Chiu Tsai  2 , Der-Yang Cho  2   3   7 , Ching-Liang Hsieh  8   9   10   11
Affiliations
Randomized Controlled Trial

PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study

Chun-Chung Chen et al. Sci Rep. .

Abstract

PG2 is an infusible polysaccharide extracted from Astragalus membranaceus, which is a Chinese herb traditionally used for stroke treatment. We investigated the effect of PG2 on patients with spontaneous acute intracerebral hemorrhage (ICH). A total of 61 patients with acute spontaneous ICH were randomized to either the treatment group (TG, 30 patients), which received 3 doses of PG2 (500 mg, IV) per week for 2 weeks, or the control group (CG, 31 patients), which received PG2 placebo. At 84 days after PG2 administration, the percentage of patients with a good Glasgow outcome scale (GOS 4-5) score in the TG was similar to that in the CG (69.0% vs. 48.4%; p = 0.2). The percentage of good mRS scores (0-2) in the TG was similar to that in the CG (62.1% vs. 45.2%; p = 0.3). In addition, no significant differences were seen when comparing differences in the C-reactive protein, erythrocyte sedimentation rate, interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α, and S100B levels between baseline and days 4, 7, and 14 after PG2 administration (all p > 0.05). The results are preliminary, necessitating a more thorough assessment.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Flowchart.
Baseline: prior to PG2 treatment; W1: 7 days after PG2 treatment; W4: 28 days after PG2 treatment; W12: 84 days after PG2 treatment; D4: Day 4 after IV PG2 injection; D7: Day 7 after IV PG2 injection; D14: Day 14 after IV PG2 injection.
See this image and copyright information in PMC

References

    1. Kase C. S & Caplan L. R. Intracerebral hemorrhage (Butterworth-Heinemann Medical, 1994).
    1. Sze K. H., Wong E., Or K. H., Lum C. M. & Woo J. Factors predicting stroke disability at discharge: a study of 793 Chinese. Archives of physical medicine and rehabilitation 81, 876–880 (2000). - PubMed
    1. Chen C. C. et al. Chinese Herb Astragalus membranaceus Enhances Recovery of Hemorrhagic Stroke: Double-Blind, Placebo-Controlled, Randomized Study. Evidence-based complementary and alternative medicine: eCAM 2012, 708452, doi: 10.1155/2012/708452 (2012). - DOI - PMC - PubMed
    1. Wei G., Ji X., Bai H. & Ding Y. Stroke research in China. Neurological research 28, 11–15, doi: 10.1179/016164106x91807 (2006). - DOI - PubMed
    1. Chen H. W. et al. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clinical and investigative medicine. Medecine clinique et experimentale 35, E1–11 (2012). - PubMed

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