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Comparative Study
. 1988 May 15;44(5):450-3.
doi: 10.1007/BF01940544.

Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds

J Pincemail  1 , C Deby, A Thirion, M de Bruyn-Dister, R Goutier
Affiliations
Comparative Study

Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds

J Pincemail et al. Experientia. .

Abstract

Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50 = 3.5 microM) and in a system using stimulated human neutrophils. Quercetin is significantly more potent than three other related compounds (rutin, rutin sulfate and troxerutin) and than methimazole, a previously-known myeloperoxidase inhibitor. The inhibitory activity of quercetin is of the competitive type. Moreover, quercetin is directly able to scavenge hypochlorous acid (HOCl), a chlorinated species generated by the MPO/H2O2/Cl- system.

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